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Thorne Methyl Guard Plus front view bottle showing active folate and 90 capsules

THORNE

Thorne Methyl-Guard Plus Active Folate 5-MTHF With Vitamins B2 B6 And B12 Homocysteine Support Supplement 90 Capsules

Why you'll like it

  • Optimized Methylation Support — Contains tissue-ready B vitamins that bypass biological conversion for maximum cellular absorption and immediate utilization.
  • Balanced Homocysteine Levels — Combines betaine anhydrous and active folate to promote healthy homocysteine metabolism and support cardiovascular health.
  • Brain and Cognitive Health — Delivers bioavailable methylcobalamin and pyridoxal 5-phosphate to maintain robust neurological function and cognitive clarity.
  • Clean Formulation — Prepared without gluten, dairy, or soy to suit individuals with sensitive dietary restrictions or allergen requirements.

Product details

Thorne Methyl-Guard Plus is an advanced nutritional supplement designed to optimize methylation pathways and support cardiovascular, cognitive, and bone health. Formulated for individuals requiring intensive methylation support or looking to maintain healthy homocysteine levels, this premium formula delivers superior methyl donors and essential B vitamins in their most bioavailable, tissue-ready forms.

By providing metabolically active nutrients, it eliminates the need for cellular conversion, ensuring maximum absorption and efficacy. This comprehensive blend features L-5-Methyltetrahydrofolate alongside methylated vitamin B12, active vitamin B6, riboflavin 5'-phosphate, and betaine anhydrous.

Free from gluten, dairy, and soy, this clean formula offers robust cellular support to promote overall arterial health, optimal neurological function, and efficient liver detoxification pathways.

Explore our full range of THORNE products — from moisturizers to cleansers, all directly sourced from the USA with authenticity guarantee. Shop more skin care at Dropy.

Take 1 to 3 capsules daily or as recommended by your healthcare practitioner.

Three Capsules Contain: Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg, Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg, Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE, Vitamin B12 (as Methylcobalamin) 3 mg, Betaine Anhydrous (Trimethylglycine) 1.8 g. Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.

As printed by the brand. Check the pack label if you have an allergy.

BrandTHORNE
GTIN00693749789017
Ships fromUSA (sourced directly), checked in Navi Mumbai
Sold byDropy.in

Ratings & reviews

From our customers

4.910 reviews
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Write a reviewThorne Methyl-Guard Plus Active Folate 5-MTHF With Vitamins B2 B6 And B12 Homocysteine Support Supplement 90 Capsules
Filter reviews10 reviews

Top reviews first: highest rated, with photos first

  • Jen
    5 ★

    Methyl-guard plus

    Only 5 days of taking it but I feel like it's doing me good

  • A. R.
    5 ★

    Love!

    Love! It's high quality, easy to take, and has really helped lower my homocysteine levels as recommended by my doctor. I appreciate that it uses active forms of B vitamins like 5-MTHF for better absorption. Thorne is such a trusted, clean brand, which gives me extra confidence in what I'm taking. I feel more balanced and energized since adding it to my routine-definitely a product I'll keep using!

  • Gary G.
    5 ★

    Dr recommended.

    Dr recommended for my MTHFR gene mutation. No odor, not taste, no after taste. No stomach issues. Hope to see the benefit in raising my folate and lowering my homocysteine and thereby lowering a risk of heart attack. .

  • Dr J.
    5 ★

    Works amazing when you really need it and know how to use it.

    I starting taking this after getting some (SpectraCell) testing done that said I was deficient in the various B vitamins and I had the MTHFR genetic defect that prevents methylation. I felt like crap for the last decade and my usual doctors weren't of any help. I eat very healthy and eat very well too as I thought that would make me better. I won't go into details but I always knew something was wrong and nothing else worked. Anyway, so i read about methyl folate and methylation, MTHFR etc. and I get this to start to "fix"it. Immediately I felt FAR worse than I ever did before. Headaches, brain fog, extreme fatigue. So I stopped taking it and I go back to the sites and learn this is normal reaction. So then I read you should boost your other B vitamins first without the methyl folate or b12 and then add this back in. So I did with a product called B Minus for about 2 months then I added this product back in. Now 2 months in to taking this I feel like I'm finally waking up and getting more energy and I feel fantastic. No side effects. And a lot of my old symptoms are gone or fading away. I held off writing a review b/c I've been so disappointed after taking so many supplements over the years but this one seems to be actually working. It can take 6 -12 months to see full results and get your levels back to where they should be so I can't imagine how I'll feel by then. I'm going to retest through Spectracell in 6 months and see where my levels are at. If you're not familiar with Spectracell, look into it. Most regular doctors won't have it and it's not covered under insurance. I actually went to a nutritionist to get it done. It's the best decision I've ever made for my health. I'm just sad that it took me so long to find the answers. Good luck to you.

Thorne Methyl-Guard Plus Active Folate 5-MTHF With Vitamins B2 B6 And B12 Homocysteine Support Supplement 90 Capsules10 customer reviews
4.9

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FAQs

What is Thorne Methyl-Guard Plus used for?

Thorne Methyl-Guard Plus is formulated to support healthy methylation pathways and maintain optimal homocysteine levels in the blood. It provides active B vitamins and methyl donors that help support cardiovascular, cognitive, nerve, and bone health.

What is the difference between Thorne Methyl-Guard and Methyl-Guard Plus?

Methyl-Guard Plus is an advanced, higher-potency formula compared to the original Methyl-Guard. It features increased amounts of active folate, vitamin B12, and vitamin B6, and introduces riboflavin 5'-phosphate (vitamin B2) to provide more intensive methylation and cardiovascular support.

When should I take Thorne Methyl-Guard Plus?

It is generally recommended to take 1 to 3 capsules daily, or follow the specific dosage guidelines provided by your healthcare professional. You can take them with a meal for optimal absorption or as directed.

Is Thorne Methyl-Guard Plus authentic and available in India?

Yes, you can secure 100% authentic Thorne products in India through Dropy. We import these supplements directly from official channels in the USA, ensuring genuine quality, proper storage conditions, and reliable delivery to your doorstep.

Can I take Thorne Methyl-Guard Plus if I have an MTHFR gene mutation?

Yes, this formula is highly beneficial for individuals with MTHFR mutations because it contains 5-MTHF, which is the pre-converted, active form of folate. This allows your body to utilize the nutrient immediately without needing the MTHFR enzyme.

How long will delivery take?

Most orders arrive in 15–20 days: we source each product directly from the USA, check it at our Navi Mumbai warehouse and pack it on video. Items marked Dropy Express ship from our India warehouse and arrive in 3–5 days.

Is cash on delivery available?

Full cash on delivery is available all over India on Dropy Express items. For other orders from ₹2,499 to ₹15,000 you can use Partial COD: pay 25% online now and the rest in cash on delivery.

Are your products genuine?

Yes. Every product is 100% authentic, sourced directly from the USA, quality-checked and packed on video at our Navi Mumbai warehouse.

What if my order arrives damaged or wrong?

Write to us at [email protected] as soon as it arrives. Damaged, wrong or not as described, our Buyer Protection gives you a full refund. The details are in our Return, Refund & Cancellation Policy.

Is delivery free?

Delivery is free on orders from ₹1,499. Below that a ₹79 delivery fee applies.